Hepatoprotective Effect of Polyherbal Formulations in Paracetamol Induced Hepatic Damaged Experimental Rats

Copyright  2014 irjpbs The aim of this work is to study the hepatoprotective effect of polyherbal formulations contains some Indian medicinal plant. The three different herbal formulations obtained from different medicinal plant extracts were evaluated for hepatoprotective in rats by induced liver damage by paracetamol. Paracetamol (3g/kg, p.o) was administered a single dose to induce hepatotoxicity. F-I, F-II and F-III (200mg/kg, p.o) and silymarin (25mg/kg, P.o) were administered once daily for 8 days. The degree of hepatoprotection was measured using morphological parameters of changing in colour, and weight liver is determined. Biochemical parameters in serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), serum alkaline phosphatase (SALP), bilirubin and plasma protein. The histopathological parameters of histological changes in the liver architecture like architecture of hepatic lobules, swelling of liver cell, fatty changes, focal necrosis, inflammatory cell infiltration around portal areas, kupffer cell hyperplasia etc. and the functional parameters of pentobarbitone sleeping time was used as a functional parameter. F-I, F-II and FIII pretreatment showed normal morphological parameters signs and significant effect of serum enzymes, total protein and bilirubin levels. Highly significantly protect the hepatodamage and morphological and histopathological changes and less pentobarbitone sleeping time were observed in all the three poly herbal formulations treated rats. Thus it could conclude that entire three polyherbal formulations possess significant hepatoprotective property against paracetamol induced hepatic damage in experimental animals.